File Name: genome wide maps of chromatin state in pluripotent and lineage committed cells .zip
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Abdi and L. Williams , Principal component analysis , Wiley interdisciplinary reviews: computational statistics , vol. Adolfsson, R. Buza-vidas, A. Hultquist, K. Liuba et al.
Protocol DOI: Dynamic protein binding to DNA elements regulates genome function and cell fate. Although methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect of genomic research, they are laborious and costly, thereby limiting. Although methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect of genomic research, they are laborious and costly, thereby limiting progress.
Maintenance and dynamic resolution of these histone marks play important roles in regulating differentiation processes in various stem cell systems. Gene ontology analysis revealed that these genes were enriched in developmental functions and differentiation processes. Microarray analyses indicated that many of these genes exhibited derepression after differentiation toward hepatocyte and cholangiocyte lineages. Among these, 72 genes, including Cdkn2a and Sox4 , were significantly upregulated after differentiation toward hepatocyte or cholangiocyte lineages. These findings implicate that derepression of Sox4 expression is required to induce normal differentiation processes. In conclusion, combined ChIP-seq and microarray analyses successfully identified bivalent genes.
Chromatin immunoprecipitation coupled with next-generation sequencing ChIP-seq has revolutionized our understanding of chromatin-related biological processes. The method, however, requires thousands of cells and has therefore limited applications in situations where cell numbers are limited. The method is simple, cost-effective and takes a single day to complete. We demonstrate the sensitivity of the method by deriving the first genome-wide maps of histone H3K4me3 and H3K27me3 modifications of inner cell mass and trophectoderm of bovine blastocyst stage embryos.
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Single-molecule-based sequencing technology is applied to generate genome-wide maps of chromatin modifications in mammalian cells.Reply
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. July ; Nature () DOI: /.Reply
In Vivo Chromatin States of the Hair Follicle Lineage. Wen-Hui contributes to maintaining pluripotency (Kirmizis et al., ;. Bernstein et Although genome-wide chromatin mapping has provided a multipotent activated SC to a differentiation-committed TA cell. These new findings illuminate how HF-SCs might induce.