genome wide maps of chromatin state in pluripotent and lineage committed cells pdf

Genome wide maps of chromatin state in pluripotent and lineage committed cells pdf

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Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Introduction

Michael T.

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Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Mikkelsen and M. Ku and D. Jaffe and Biju Issac and E.

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Abdi and L. Williams , Principal component analysis , Wiley interdisciplinary reviews: computational statistics , vol. Adolfsson, R. Buza-vidas, A. Hultquist, K. Liuba et al.

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Protocol DOI: Dynamic protein binding to DNA elements regulates genome function and cell fate. Although methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect of genomic research, they are laborious and costly, thereby limiting. Although methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect of genomic research, they are laborious and costly, thereby limiting progress.

Introduction

Maintenance and dynamic resolution of these histone marks play important roles in regulating differentiation processes in various stem cell systems. Gene ontology analysis revealed that these genes were enriched in developmental functions and differentiation processes. Microarray analyses indicated that many of these genes exhibited derepression after differentiation toward hepatocyte and cholangiocyte lineages. Among these, 72 genes, including Cdkn2a and Sox4 , were significantly upregulated after differentiation toward hepatocyte or cholangiocyte lineages. These findings implicate that derepression of Sox4 expression is required to induce normal differentiation processes. In conclusion, combined ChIP-seq and microarray analyses successfully identified bivalent genes.

Chromatin immunoprecipitation coupled with next-generation sequencing ChIP-seq has revolutionized our understanding of chromatin-related biological processes. The method, however, requires thousands of cells and has therefore limited applications in situations where cell numbers are limited. The method is simple, cost-effective and takes a single day to complete. We demonstrate the sensitivity of the method by deriving the first genome-wide maps of histone H3K4me3 and H3K27me3 modifications of inner cell mass and trophectoderm of bovine blastocyst stage embryos.

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Genome-wide analysis of epigenetic dynamics across human developmental stages and tissues

4 comments

  • Raquel T. 11.11.2020 at 20:21

    Single-molecule-based sequencing technology is applied to generate genome-​wide maps of chromatin modifications in mammalian cells.

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  • Zoe S. 18.11.2020 at 15:16

    Genome-wide maps of chromatin state in pluripotent and lineage-committed cells​. July ; Nature () DOI: /.

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In Vivo Chromatin States of the Hair Follicle Lineage. Wen-Hui contributes to maintaining pluripotency (Kirmizis et al., ;. Bernstein et Although genome-​wide chromatin mapping has provided a multipotent activated SC to a differentiation-committed TA cell. These new findings illuminate how HF-SCs might induce.