File Name: aggrecan is expressed by embryonic brain glia and regulates astrocyte development .zip
Glial cells in the central nervous system CNS contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efficient neurotransmission and axon potential propagation. In the normal adult CNS, the extracellular matrix ECM is relatively stable except in selected regions characterized by dynamic remodeling. However, after trauma such as a spinal cord injury or cortical contusion, the lesion epicenter becomes a focus of acute neuroinflammation. An advantage of this response is to limit the invasion of damaging cells and diffusion of toxic molecules into the spared tissue regions, but this occurs at the cost of inhibiting migration of endogenous repair cells and preventing axonal regrowth. This article highlights structural and functional features of the normal adult CNS ECM and then focuses on the reactions of glial cells and changes in the perilesion border that occur following spinal cord or contusive brain injury.
Synapses are specialized structures that mediate rapid and efficient signal transmission between neurons and are surrounded by glial cells. Astrocytes develop an intimate association with synapses in the central nervous system CNS and contribute to the regulation of ion and neurotransmitter concentrations. Together with neurons, they shape intercellular space to provide a stable milieu for neuronal activity. Extracellular matrix ECM components are synthesized by both neurons and astrocytes and play an important role in the formation, maintenance, and function of synapses in the CNS. The components of the ECM have been detected near glial processes, which abut onto the CNS synaptic unit, where they are part of the specialized macromolecular assemblies, termed perineuronal nets PNNs.
Aggrecan expressed by embryonic glial cells in the brain is an astrocyte developmental regulator . Chick aggrecan nanomelia mutants display marked.
Metrics details. Traumatic brain injury TBI is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brain.
Neurons and glial cells in the central nervous system are tightly associated to each other, maintaining physiological homeostasis of the human body. In addition to the cell-cell interaction, the CNS is also composed of elaborated and complicated extracellular matrixes ECMs. Neural ECMs are radically different from those of other tissues. The interstitial ECMs are mainly composed of a loose meshwork of hyaluronan, sulfated proteoglycans, and tenascins 1 , 2.
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans aggrecan, versican, neurocan, brevican, phosphacan , link proteins and tenascins Tn-R, Tn-C can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support.
Request PDF | Aggrecan is expressed by embryonic brain glia and regulates astrocyte development | Determination of the molecules that.Reply
Determination of the molecules that regulate astrocyte development has been hindered by the paucity of markers that identify astrocytic.Reply